System dynamics modelling in systems biology and applications in pharmacology

El modelado matemático de sistemas biológicos complejos es uno de los temas clave en la Biología de Sistemas y varios métodos computacionales basados ​​en la simulación computarizada han sido aplicados hasta ahora para determinar el comportamiento de los sistemas no lineales. La Dinamica de Sistemas es una metodología de modelado intuitivo basada en el razonamiento cualitativo por el cual un modelo conceptual se puede describir como un conjunto de relaciones de causa y efecto entre las variables de un sistema. A partir de esta estructura, es posible obtener un conjunto de ecuaciones dinámicas que describan cuantitativamente el comportamiento del sistema. Centrándose en los sistemas farmacológicos, el modelado compartimental a menudo se utiliza para resolver un amplio espectro de problemas relacionados con la distribución de materiales en los sistemas vivos en la investigación, el diagnóstico y la terapia en todo el cuerpo, los órganos y los niveles celulares. En este artículo presentamos la metodología de modelado de Dinámica del Sistema y su aplicación al modelado de un modelo compartimental farmacocinético-farmacodinámico del efecto de profundidad anestésica en pacientes sometidos a intervenciones quirúrgicas, derivando un modelo de simulación en el entorno de simulación orientada a objetos OpenModelica. La Dinamica de Sistemas se puede ver como una herramienta educativa poderosa y fácil de usar y en la enseñanza de Biología de Sistemas.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Relative Morsification Theory

In this paper we develope a Morsification Theory for holomorphic functions defining a singularity of finite codimension with respect to an ideal, which recovers most previously known Morsification results for non-isolated singulatities and generalize them to a much wider context. We also show that deforming functions of finite codimension with respect to an ideal within the same ideal respects the Milnor fibration. Furthermore we present some applications of the theory: we introduce new numerical invariants for non-isolated singularities, which explain various aspects of the deformation of functions within an ideal; we define generalizations of the bifurcation variety in the versal unfolding of isolated singularities; applications of the theory to the topological study of the Milnor fibration of non-isolated singularities are presented. Using intersection theory in a generalized jet-space we show how to interprete the newly defined invariants as certain intersection multiplicities; finally, we characterize which invariants can be interpreted as intersection multiplicities in the above mentioned generalized jet space.Comment: 56 pages, some typos correcte

Comment on: 'A simple analytical expression for bound state energies for an attractive Gaussian confining potential'

We discuss a recently proposed analytical formula for the eigenvalues of the Gaussian well and compare it with the analytical expression provided by the variational method with the simplest trial function. The latter yields considerably more accurate results than the former for the energies and critical parameters

Eigenvalues and eigenfunctions of the anharmonic oscillator V(x,y)=x2y2V(x,y)=x^{2}y^{2}

We obtain sufficiently accurate eigenvalues and eigenfunctions for the anharmonic oscillator with potential $V(x,y)=x^{2}y^{2}$ by means of three different methods. Our results strongly suggest that the spectrum of this oscillator is discrete in agreement with early rigorous mathematical proofs and against a recent statement that cast doubts about it

Personal aircraft: a more affordable luxury

Access to luxury products has been limited traditionally to the upper classes. Products and services related to the means of transport have usually been considered of luxury and industrialization has made accessible to much of the population in developed countries. An emerging market is personal aircraft which is currently restricted to certain layers of society but it is expected that their use will represent the next great advance in transport. This article has the object of presenting the results of ongoing research and it focuses on possible demand and the tendency to use this transport option in Spanish societ